Automated Right Heart Assessment for Pulmonary Hypertension
Us2.ai is the first AI system validated for fully automated right heart echocardiographic analysis in pulmonary hypertension, delivering every guideline-recommended parameter without manual interaction.
A Deadly Disease That Hides in the Right Heart
Pulmonary hypertension is frequently diagnosed late because the right ventricle is difficult to assess manually. Delayed diagnosis means patients miss the window for effective therapy.
Patients with pulmonary arterial hypertension experience years of diagnostic delay on average. By the time PH is recognized, many patients have advanced right heart dysfunction.
PAH disproportionately affects women, with a mean age of 48 at diagnosis. The disease is progressive and fatal without treatment, making early detection essential.
PH spans five distinct clinical groups with different etiologies and treatments. Echocardiography is the front-line screening tool that triggers the diagnostic pathway for all of them.
The RV's asymmetric shape, prominent trabeculations, and abnormal septal motion in PH make manual echocardiographic measurements time-consuming and prone to variability. This is why right heart analysis has lagged behind the left heart in AI development.
Every Guideline Parameter, Fully Automated
International guidelines include echocardiographic metrics in both PH diagnosis and risk stratification. Us2.ai delivers all of them, from view classification through measurement, without human intervention.
Peak Tricuspid Regurgitation Velocity
Peak TRV is the primary echocardiographic marker for estimating pulmonary artery systolic pressure and screening for PH. Us2.ai automatically identifies CW Doppler TR signals and traces the velocity envelope with ρ = 0.90 correlation to expert core lab measurements.
TAPSE
Tricuspid annular plane systolic excursion is a key measure of RV longitudinal function and a guideline-recommended risk stratification parameter. Us2.ai measures TAPSE automatically with ρ = 0.78 correlation and less than 2% bias versus expert readers.
Right Atrial Area
RA area reflects right heart filling pressures and is included in international guidelines' risk assessment. Us2.ai segments the right atrium automatically with ρ = 0.86 correlation. This parameter is particularly difficult and time-consuming to measure manually.
RV Size & Function
RV basal diameter, end-diastolic area, end-systolic area, and fractional area change provide comprehensive assessment of RV remodeling and systolic function. Us2.ai delivers all four measurements automatically from the RV-focused apical view.
Prior to this study, no AI system had been validated for a fully automated right heart analysis workflow in pulmonary hypertension. Us2.ai performs the complete pipeline (view classification, view selection, segmentation, and measurement) without any manual interaction, achieving measurement yields above 90% for peak TRV and TAPSE.
Independently Validated and Peer-Reviewed
Us2.ai's right heart analysis was independently evaluated by Stanford University in a study published in CHEST, a leading pulmonology and critical care journal.
Near-Expert Discrimination
For distinguishing PAH from healthy controls, Us2.ai achieved AUC 0.98 for peak TRV, compared to AUC 0.99 for expert core lab readers. For the harder task of detecting mild PH in a referral cohort, the AI showed no statistically significant difference from clinical reads.
Low Bias on Critical Parameters
For peak TRV, TAPSE, and RA area (the three most important PH echo markers) Us2.ai demonstrated less than 2% relative bias compared to expert core lab measurements. Precision remained within clinical thresholds for all guideline parameters.
Independent Stanford Evaluation
Data acquisition and analysis were performed independently by Stanford University researchers. The study included 221 PAH patients and 213 healthy controls, the largest AI validation cohort for right heart echocardiography in PH to date.
Us2.ai Accuracy: AI vs. Expert Core Lab
Stanford-validated. Fully automated. Published in CHEST.
Automate Right Heart Assessment on Every Echo
Us2.ai delivers peak TRV, TAPSE, RA area, and complete RV assessment, automatically on every scan, enabling PH screening at scale.